Box-Jenkins intervention analysis of Functional Magnetic Resonance ImagingFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. data
Data obtained in Functional Magnetic Resonance ImagingFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. typically form a time series of MRI signal collected over a period of time at constant intervals. These data are potentially autocorrelated and may contain time trends. Therefore, any assessment of significant changes in the MRI signal over a certain period of time requires the use of specific statistical techniques. For that purpose we used the Box-Jenkins intervention time series analysis to determine brain activation during task performance. We found that for a substantial number of pixels there was significant autocorrelation and, occasionally, time trends. In these cases, use of the classical t-test would not be appropriate. In contrast, Box-Jenkins intervention analysis, by detrending the series and by explicitly taking into account the correlation structure, provides a more appropriate method to determine the presence of significant activation during the task period in fMRIFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. data.