Art Leuthold, PhD
Magnetoencephalography Magnetoencephalography (MEG)A noninvasive technique that detects magnetic fields above the surface of the head produced by postsynaptic potentials in the brain. Site Manager, Brain Sciences CenterBrain Sciences Center (BSC)
Physicist, Minneapolis VA Medical CenterVA Medical Center (VAMC)
Assistant Professor Neuroscience, University of Minnesota
Physicist, Minneapolis VAMCVA Medical Center (VAMC)

leuth004@umn.edu

Education
PhD, Medical Physics, University of Wisconsin
MS, Medical Physics, University of Wisconsin
BS, Physics, Chemistry, University of Wisconsin

Specialty/Focus
MEGMagnetoencephalography (MEG)A noninvasive technique that detects magnetic fields above the surface of the head produced by postsynaptic potentials in the brain. signal processing and methods development aimed at the study of basic brain systems

Publications

Pages: 1March 2023 through January 2013 • 2October 2012 through November 2005 • 3November 2005 through September 1994
  1. Spatiotemporal neural interactions underlying continuous drawing movements as revealed by magnetoencephalography Experimental Brain Research (2012, October) Christopoulos V, Leuthold A, & Georgopoulos AP
  2. Canonical correlation analysis of Synchronous Neural InteractionsSynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. and cognitive deficits in Alzheimer's dementia Journal of Neural Engineering (2012, August) Karageorgiou E, Lewis S, McCarten JR, Leuthold A, Hemmy LS, McPherson SE, Rottunda SJ, Rubins D, & Georgopoulos AP
  3. Differential brain activity states during the perception and nonperception of illusory motion as revealed by magnetoencephalography Proceedings of the National Academy of Sciences of the United States of America (2010, December) Crowe D, Leuthold A, & Georgopoulos AP
  4. Post-traumatic Stress DisorderPost-traumatic Stress Disorder (PTSD)A complex psychiatric syndrome that develops in response to trauma exposure. Individuals with PTSD experience intrusive recollections or reexperiencing of the traumatic event, avoidance of trauma reminders, emotional numbing, and hyperarousal. In addition, PTSD is associated with high rates of concomitant physical and mental health problems, increased health care use, and impairment in social and occupational functioning. Almost 7% of the general population and up to 30% of veterans meet lifetime criteria for PTSD. Indeed, PTSD is one of the most common psychiatric disorders, representing a significant and costly public health concern.: a right temporal lobe syndrome? Journal of Neural Engineering (2010, October) Engdahl B, Leuthold A, Tan HRM, Lewis S, Winskowski AM, Dikel TN, & Georgopoulos AP
  5. Beta-Band Activity during Motor Planning Reflects Response Uncertainty Journal of Neuroscience (2010, August) Tzagarakis C, Ince NF, Leuthold A, & Pellizzer G
  6. Cortical processing of facial tactile stimuli in temporomandibular disorder as revealed by magnetoencephalography Experimental Brain Research (2010, July) Alonso A, Koutlas I, Leuthold A, Lewis S, & Georgopoulos AP
  7. A magnetoencephalography study of choice bias Experimental Brain Research (2010, April) Hedgcock WM, Crowe D, Leuthold A, & Georgopoulos AP
  8. The SNISynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. test as a functional neuromarker for PTSDPost-traumatic Stress Disorder (PTSD)A complex psychiatric syndrome that develops in response to trauma exposure. Individuals with PTSD experience intrusive recollections or reexperiencing of the traumatic event, avoidance of trauma reminders, emotional numbing, and hyperarousal. In addition, PTSD is associated with high rates of concomitant physical and mental health problems, increased health care use, and impairment in social and occupational functioning. Almost 7% of the general population and up to 30% of veterans meet lifetime criteria for PTSD. Indeed, PTSD is one of the most common psychiatric disorders, representing a significant and costly public health concern.: a robust classification method based on the bootstrap Journal of Neural Engineering (2010, January) Georgopoulos AP, Tan HRM, Lewis S, Leuthold A, Winskowski AM, Lynch J, & Engdahl B
  9. Neural mechanisms of movement speed and tau as revealed by magnetoencephalography Experimental Brain Research (2009, June) Tan HRM, Leuthold A, Lee D, Lynch J, & Georgopoulos AP
  10. Classification of schizophrenia with spectro-temporo-spatial MEGMagnetoencephalography (MEG)A noninvasive technique that detects magnetic fields above the surface of the head produced by postsynaptic potentials in the brain. patterns in working memory Clinical Neurophysiology (2009, June) Ince NF, Pellizzer G, Tewfik AH, Nelson K, Leuthold A, McClannahan K, & Stephane M
  11. Temporospatial Characterization of Brain Oscillations (TSCBO) Associated with Subprocesses of Verbal Working Memory in Schizophrenia Clinical EEG and Neuroscience (2008, October) Stephane M, Ince NF, Leuthold A, Pellizzer G, Tewfik AH, Surerus C, Kuskowski MA, & McClannahan K
  12. Cortical processing of tactile stimuli applied in quick succession across the fingertips: temporal evolution of dipole sources revealed by magnetoencephalography Experimental Brain Research (2008, August) Karageorgiou E, Koutlas I, Alonso A, Leuthold A, Lewis S, & Georgopoulos AP
  13. P2-027: Association of cognitive deficits with SNISynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. as revealed by magnetoencephalography: A canonical correlation analysis Alzheimer's & Dementia (2008, July) Karageorgiou E, Lewis S, McCarten JR, Leuthold A, Hemmy LS, McPherson SE, Rottunda SJ, & Georgopoulos AP
  14. SNISynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. assessed by magnetoencephalography: a functional biomarker for brain disorders Journal of Neural Engineering (2007, August) Georgopoulos AP, Karageorgiou E, Leuthold A, Lewis S, Lynch J, Alonso A, Aslam Z, Carpenter A, Georgopoulos A, Hemmy LS, Koutlas I, Langheim F, McCarten JR, McPherson SE, Pardo J, Pardo P, Parry GJ, Rottunda SJ, Segal BM, Sponheim S, Stanwyck JJ, Stephane M, & Westermeyer JJ
  15. Reading in a deep orthography: neuromagnetic evidence for dual-mechanisms Experimental Brain Research (2007, June) Wilson T, Leuthold A, Moran JE, Pardo P, Lewis S, & Georgopoulos AP
  16. Paving the way for cross-site pooling of MEGMagnetoencephalography (MEG)A noninvasive technique that detects magnetic fields above the surface of the head produced by postsynaptic potentials in the brain. data International Congress Series (2007, June) Weisend MP, Hanlon FM, Montano R, Ahlfors SP, Leuthold A, Pantazis D, Mosher JC, Georgopoulos AP, Hamalainen MS, & Aine CJ
  17. Assessment of Fetal Rhythm in Complete Congenital Heart Block by Magnetocardiography Pacing and Clinical Electrophysiology (2006, June) Wakai RT, Leuthold A, Cripe L, & Martin CB
  18. Dipole analysis of magnetoencephalographic data during continuous shape copying Experimental Brain Research (2006, April) Langheim F, Merkle AN, Leuthold A, Lewis S, & Georgopoulos AP
  19. Synchronous dynamic brain networks revealed by magnetoencephalography Proceedings of the National Academy of Sciences of the United States of America (2006, January) Langheim F, Leuthold A, & Georgopoulos AP
  20. Magnetoencephalographic signals predict movement trajectory in space Experimental Brain Research (2005, November) Georgopoulos AP, Langheim F, Leuthold A, & Merkle AN