Human Connectome Project

Brain Sciences CenterBrain Sciences Center (BSC) investigators are currently utilizing open access, neuroimaging data from the NIH Human Connectome Project to examine various topics including heritability of functional brain connectivity, age-related brain changes, and sex differences in brain aging.

Related Publications & Stories

  1. Negative association between neurovascular coupling and cortical gray matter volume during the lifespan Journal of Neurophysiology (2024, March) Christova P, James L, & Georgopoulos AP
  2. Changes of gray matter volumes of subcortical regions across the lifespan: a Human Connectome Project study Journal of Neurophysiology (2023, November) Christova P, & Georgopoulos AP
  3. JNP Micro Podcasts Journal of Neurophysiology (2023, August) Georgopoulos AP
  4. Changes of cortical gray matter volume during development: a Human Connectome Project study Journal of Neurophysiology (2023, June) Christova P, & Georgopoulos AP
  5. Differential reduction of gray matter volume with age in 35 cortical areas in men (more) and women (less) Journal of Neurophysiology (2023, April) Christova P, & Georgopoulos AP
  6. Heritability of brain neurovascular coupling Journal of Neurophysiology (2022, November) Christova P, & Georgopoulos AP
  7. Functional cortical associations and their intraclass correlations and heritability as revealed by the Functional Magnetic Resonance ImagingFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. Human Connectome Project Experimental Brain Research (2022, March) Christova P, Joseph J, & Georgopoulos AP
  8. Effects of sex and age on presumed inhibitory interactions in 6 areas of the human cerebral cortex as revealed by the fMRIFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. Human Connectome Project Experimental Brain Research (2022, January) Christova P, James L, & Georgopoulos AP